Model of a Squid Axon in iCell
A.L. Hodgkin and A.F. Huxley, 1952  

This is a JAVA-based simulation of the electrical activity in a squid axon model. The model was developed by the equations presented in A Quantitative Description of Membrane Current and its Application to Conduction and Excitation in a Nerve (A.L. Hodgkin and A.F. Huxley, Journal of Physiology 117: 500-544, 1952).

Electrical Equivalent Circuit of the Membrane

Parameters

g_k, g_na, and g_l are the ionic conductances of potassium, sodium, and leakage channels, respectively, in units of mS/cm².

end time is the end of the simulation time (in milliseconds).

stim amp. is the amplitude of the stimulus current applied in microamperes/cm².

stim time is the application duration of the stimulus current in milliseconds.

Instructions

Click on "REDRAW" to calculate and draw the graph.

Enter new values, if desired.

Enter a new value for end time, the maximum displayed time in milliseconds.

g_k, g_na, g_l, and end time will default to the maximum or minimum allowed value if certain limits are exceeded.

Click "RESET" to set stim amp, stim time, g_k, g_na, and g_l to their default (control) values.

Click within the graphic area to find the millisecond and millivolt values at that point.

Select from "choose figures" to display the membrane voltage, the ionic currents.

Model Development by Semahat S. Demir and JAVA(tm) "squid" Applet by Joe McManis and Yiming Liu

Cell model equations and parameters taken from the C source codes
of Semahat S. Demir

Last updated Sept. 29, 1999 by Yiming Liu

Web development and design by Semahat S. Demir